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Euphoria may be experienced by those who suffer from bipolar depression (manic depression) in the manic phase. It may occasionally be seen in other psychiatric disorders, such as schizophrenia, in which emotional responses and perceptions of reality are abnormal. A number of recreational and illegal drugs have been described as having an effect of inducing euphoria.

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People are more susceptible if they are taking medications that prevent normal blood clotting. Other predisposing factors include infection, trauma, allergic and non-allergic rhinitis, hypertension, alcohol abuse, and inherited bleeding problems.

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